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(±)-Verapamil . hydrochloride

Ca2+ channel inhibitor
ALX-550-306-G001 1 g 45.00 USD
ALX-550-306-G005 5 g 127.00 USD
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Replaces Prod. #: BML-CA215

Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines.

Product Details

Alternative Name:5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl
Formula:C27H38N2O4 . HCl
MW:454.6 . 36.5
MI:14: 9950
Purity:≥99% (HPLC)
Identity:Determined by IR.
Appearance:White crystalline powder.
Solubility:Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes: M. Takiyama, et al.; Xenobiotica 52, 511 (2022), Abstract;
Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice: T. Matsumoto, et al.; J. Ethnopharmacol. 279, 114332 (2021), Abstract;
Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells: W. C. Chen, et al.; Nat. Commun. 12, 4288 (2021), Abstract;
Short-term exposure to L-type calcium channel blocker, verapamil, alters the expression pattern of calcium-binding proteins in the brain of goldfish, Carassius auratus: N.V. Palande, et al.; Comp. Biochem. Physiol. C: Tocicol. Pharmacol. 176-177, 31 (2015), Application(s): Cell culture in fish, Abstract;
Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line: I.B. Shchepotin, et al.; Int. J. Hyperthermia 13, 547 (1997), Abstract;
Hyperthermia and verapamil inhibit the growth of human colon cancer xenografts in vivo through apoptosis: I.B. Shchepotin, et al.; Anticancer Res. 17, 2213 (1997), Abstract;
Neuron degeneration induced by verapamil and attenuated by EGb761: L. Zhu, et al.; J. Basic Clin. Physiol. Pharmacol. 8, 301 (1997), Abstract;
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res. 14, 1027 (1994), Abstract;
Effect of high-dose verapamil administration on the Ca2+ channel density in rat cardiac tissue: B.B. Lonsberry, et al.; Pharmacology 49, 23 (1994), Abstract;
Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex: D. Piwnica-Worms, et al.; Cancer Res. 53, 977 (1993), Abstract;
Goodman and Gilman's The Pharmacological Basis of Therapeutics, vol. 8; p. 774 (1990),
Drug action and cellular calcium regulation: R. Janis, et al.; Adv. Drug Res. 16, 309 (1987),
Calcium antagonism and calcium entry blockade: T. Godfraind, et al.; Pharmacol. Rev. 38, 321 (1986), Abstract;
Participation of intracellular sites in the action of Ca2+ channel blockers: E.J. White & H.F. Bradford; Eur. J. Pharmacol. 130, 243 (1986), Abstract;
The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site: R.H. Zobrist, et al.; J. Mol. Cell. Cardiol. 18, 963 (1986), Abstract;
Effect of trifluoperazine, compound 48/80, TMB-8 and verapamil on the rate of calmodulin binding to erythrocyte Ca2+-ATPase: O. Scharff & B. Foder; Biochim. Biophys. Acta 772, 29 (1984), Abstract;
alpha-adrenergic antagonists as possible calcium channel inhibitors: D. Atlas & M. Adler; PNAS 78, 1237 (1981), Abstract;
Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle: A. Fleckenstein; Ann. Rev. Pharmacol. 17, 149 (1977), Abstract;

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