Potent TRPV1 agonist (Ki=19nM). About 300-fold more potent than capsaicin (Prod. No. BML-EI125). RTX binding affinity (Ki=17.4nM), agonism (calcium influx; EC50=1.97nM).
Product Details
| Alternative Name: | 2-(3,4-Dimethylbenzyl)-3-{[(4-hydroxy-3-methoxy-benzyl)amino]carbothioyl}propyl pivalate, Vanilloid Receptor Agonist 23 |
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| Formula: | C26H36N2O4S |
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| MW: | 472.6 |
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| Purity: | ≥98% |
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| Appearance: | Off-white to yellow sticky solid. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
10, 1171 (2002),
Abstract;
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
9, 19 (2001),
Abstract;
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