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Amiloride, 5-(N-Ethyl-N-isopropyl)-

Na+/H+ antiporter inhibitor
 
ALX-550-266-M005 5 mg 65.00 USD
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Selective inhibitor of the Na /H antiporter.

Product Specification

Alternative Name:5-(N-Ethyl-N-isopropyl)amiloride, EIPA
 
Formula:C11H18ClN7O
 
MW:299.8
 
CAS:1154-25-2
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:Off-white to yellow solid.
 
Solubility:Soluble in methanol, DMSO or dilute aqueous acid; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
ALX-550-266
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ALX-550-266

Product Literature References

Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells: Y. Takashina, et al.; Nutrients 10, E1345 (2018), Abstract;
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity: S. Watanabe, et al.; Cell Death Dis. 5, e1497 (2014), Application(s): Treatment of N2a mouse neuroblastoma cells, Abstract; Full Text
The signalling imprints of nanoparticle uptake by bone marrow derived dendritic cells: L. Karlson Tde, et al.; Methods 60, 275 (2013), Abstract;
Apical membrane Na+/H+ exchange in rat medullary thick ascending limb. pH-dependence and inhibition by hyperosmolality: B.A. Watts III & D.W. Good; J. Biol. Chem. 269, 20250 (1994), Abstract; Full Text
Regulation of intracellular pH in crypt cells from rabbit distal colon: S.L. Abrahamse, et al.; Am. J. Physiol. 267, G409 (1994), Abstract;
Influence of atrial natriuretic factor on 5-(N-ethyl-N- isopropyl)amiloride-sensitive 22Na+ uptake in rabbit aorta: S. Gupta, et al.; J. Pharmacol. Exp. Ther. 248, 991 (1989), Abstract;

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