Selective inhibitor of the Na /H antiporter.
Product Details
| Alternative Name: | 5-(N-Ethyl-N-isopropyl)amiloride, EIPA |
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| Formula: | C11H18ClN7O |
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| MW: | 299.8 |
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| CAS: | 1154-25-2 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Off-white to yellow solid. |
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| Solubility: | Soluble in methanol, DMSO or dilute aqueous acid; insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells: Y. Takashina, et al.; Nutrients
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Abstract;
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity: S. Watanabe, et al.; Cell Death Dis.
5, e1497 (2014),
Application(s): Treatment of N2a mouse neuroblastoma cells,
Abstract;
Full Text
The signalling imprints of nanoparticle uptake by bone marrow derived dendritic cells: L. Karlson Tde, et al.; Methods
60, 275 (2013),
Abstract;
Apical membrane Na+/H+ exchange in rat medullary thick ascending limb. pH-dependence and inhibition by hyperosmolality: B.A. Watts III & D.W. Good; J. Biol. Chem.
269, 20250 (1994),
Abstract;
Full Text
Regulation of intracellular pH in crypt cells from rabbit distal colon: S.L. Abrahamse, et al.; Am. J. Physiol.
267, G409 (1994),
Abstract;
Influence of atrial natriuretic factor on 5-(N-ethyl-N- isopropyl)amiloride-sensitive 22Na+ uptake in rabbit aorta: S. Gupta, et al.; J. Pharmacol. Exp. Ther.
248, 991 (1989),
Abstract;
