Na+/H+ antiporter inhibitor (IC50=6.9 µM) with increased selectivity and potency relative to amiloride (Prod. No. ALX-550-212).
Product Details
| Alternative Name: | 5-(N,N-Dimethyl)amiloride . HCl, DMA . HCl |
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| Formula: | C8H12ClN7O . HCl |
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| MW: | 257.7 . 36.5 |
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| CAS: | 1214-79-5 (free base) |
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| Purity: | ≥97% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in methanol (10mg/ml) or water (6mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa: Y.Tsuchiya, et al.; J. Nutr. Sci. Vitaminol. (Tokyo)
64, 287 (2018),
Abstract;
Full Text
Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart: J. Arakawa & A. Hara; Pharmacology
59, 239 (1999),
Abstract;
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger: L. Mirossay, et al.; Physiol. Res.
48, 135 (1999),
Abstract;
Involvement of sodium in the protective effect of 5-(N,N-dimethyl)- amiloride on ischemia-reperfusion injury in isolated rat ventricular wall: H. Meng & G.N. Pierce; J. Pharmacol. Exp. Ther.
256, 1094 (1991),
Abstract;
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman & E.J. Cragoe Jr.; J. Membr. Biol.
105, 1 (1988),
Abstract;
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