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K+ channel activator
ALX-550-260-M500 500 mg 165.00 USD
ALX-550-260-G001 1 g 298.00 USD
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Replaces Prod. #: BML-KC115

ATP-sensitive K+ channel activator. Effective concentrations in patch clamp experiments: 100-600µM. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.

Product Details

Alternative Name:7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
MI:14: 3004
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO (25mg/ml); insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992), Abstract;
Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists: M.J. Dunne et al.; Br. J. Pharmacol. 103, 1847 (1991), Abstract;
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990), Abstract;
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990), Abstract;
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989), Abstract;
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989), Abstract;
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line: N.C. Strugess et al.; Br. J. Pharmacol. 95, 83 (1988), Abstract;
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986), Abstract;

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Pinacidil . monohydrate 

K+ channel activator
85371-64-8, ≥98% (HPLC) | Print as PDF
ALX-550-285-M050 50 mg 73.00 USD
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