Replaces Prod. #: BML-KC115
ATP-sensitive K+ channel activator. Effective concentrations in patch clamp experiments: 100-600µM. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.
Product Details
| Alternative Name: | 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide |
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| Formula: | C8H7ClN2O2S |
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| MW: | 230.7 |
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| CAS: | 364-98-7 |
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| MI: | 14: 3004 |
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| RTECS: | DK8185000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (25mg/ml); insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol.
107, 87 (1992),
Abstract;
Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists: M.J. Dunne et al.; Br. J. Pharmacol.
103, 1847 (1991),
Abstract;
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol.
114, 53 (1990),
Abstract;
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol.
100, 605 (1990),
Abstract;
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther.
250, 261 (1989),
Abstract;
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett.
250, 262 (1989),
Abstract;
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line: N.C. Strugess et al.; Br. J. Pharmacol.
95, 83 (1988),
Abstract;
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol.
407, 493 (1986),
Abstract;
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