Non-selective Ca2+ channel blocker. At nanomolar concentrations, binds to opioid μ-receptors. Does not cross the blood brain barrier.
Product Details
| Alternative Name: | 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide . HCl |
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| Formula: | C29H33ClN2O2 . HCl |
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| MW: | 477.0 . 36.5 |
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| CAS: | 34552-83-5 |
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| MI: | 14: 5571 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in methanol or chloroform. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis.
9, 994 (2018),
Abstract;
Full Text
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects: I.J. Reynolds, et al.; J. Pharmacol. Exp. Ther.
231, 628 (1984),
Abstract;
