Replaces Prod. #: BML-CA245
A potent L-type Ca2+ channel opener. Induces a contractile response in cardiac and vascular smooth muscle, EC50=0.2µM.
Product Details
| Alternative Name: | 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester |
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| Formula: | C22H21NO3 |
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| MW: | 347.4 |
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| CAS: | 120934-96-5 |
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| Purity: | ≥98% |
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| Appearance: | White to tan powder. |
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| Solubility: | Soluble in 100% ethanol (2mg/ml) or DMSO (10mg/ml); insoluble in aqueous solution. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176: D. Rampe, et al.; J. Pharmacol. Exp. Ther.
265, 1125 (1993),
Abstract;
A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176: D. Rampe & A.E. Lacerda; J. Pharmacol. Exp. Ther.
259, 982 (1991),
Abstract;
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations: W. Zheng, et al.; Mol. Pharmacol.
40, 734 (1991),
Abstract;
