Potent and selective NMDA receptor glycine site antagonist.
Product Details
| Alternative Name: | ACEA-1021 |
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| Formula: | C8H3Cl2N3O4 |
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| MW: | 276.0 |
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| CAS: | 153504-81-5 |
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| Purity: | ≥98% (TLC; elemental analysis) |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO or dilute aqueous base. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D- aspartate receptor glycine sites: R.M. Woodward, et al.; Mol. Pharmacol.
47, 568 (1995),
Abstract;
Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3- quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist: R.M. Woodward, et al.; J. Pharmacol. Exp. Ther.
275, 1209 (1995),
Abstract;
Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors: J.F.W. Keana, et al.; J. Med. Chem.
38, 4367 (1995),
Abstract;
