Replaces Prod. #: BML-CA200
Selectively blocks low threshold (T-type) calcium channel (KD=30μM) with no effect on L-type channels or tetrodotoxin Na+ channels. Inhibits the epithelial tetrodotoxin insensitive Na+ channel (IC50 =1μM). Clinically useful K+ sparing diuretic.
Product Details
| Alternative Name: | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide . HCl . 2H2O |
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| Formula: | C6H8ClN7O . HCl . 2H2O |
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| MW: | 229.6 . 36.5 . 36.0 |
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| CAS: | 17440-83-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Light yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or water (1mg/ml warm). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa: Y. Tsuchiya, et al.; J. Nutr. Sci. Vitaminol. (Tokyo)
64, 287 (2018),
Abstract;
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Inhibitory effects of amiloride and its analogues on prostaglandin E2-stimulated fluid transport by cultured porcine thyroid cells: evidence for apical membrane Na+ channels: T. Matainaho, et al.; J. Endocrinol.
123, 93 (1989),
Abstract;
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman and E.J. Kragoe Jr.; J. Membr. Biol.
105, 1 (1988),
Abstract;
Amiloride selectively blocks the low threshold (T) calcium channel: C.-M. Tang, et al.; Science
240, 213 (1988),
Abstract;
The amiloride-sensitive sodium channel: S. Sariban-Sohraby & D.J. Benos; Am. J. Physiol.
250, C175 (1986),
Abstract;
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intell. Clin. Pharm.
15, 94 (1981),
Abstract;
