Potent and selective non-peptide NK1 tachykinin receptor antagonist.
Product Specification
| Alternative Name: | cis-2-(Diphenylmethyl)-N-[(2-iodophenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine . oxalate |
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| Formula: | C27H29N2I . C2H2O4 |
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| MW: | 508.5 . 90.0 |
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| CAS: | 144425-84-3 |
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| Purity: | ≥96% |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in methanol or DMSO; slightly soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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Product Literature References
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice - potential role of TRPA1 in osteoarthritis: L.J. Moilanen, et al.; Osteoarthritis Cartilage
23, 2017 (2015),
Application(s): Cell culture ,
Abstract;
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor: M.A. Cascieri, et al.; Mol. Pharmacol.
42, 458 (1992),
Abstract;
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor: T.M. Fong, et al.; J. Biol. Chem.
267, 25664 (1992),
Abstract;
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