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Mixed mGluR agonist and antagonist
ALX-550-119-M001 1 mg 35.00 USD
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Agonist for group II mGluRs. Competitive antagonist for group I mGluR1; mixed effects at mGluR5.

Product Details

Alternative Name:(S)-4-Carboxy-3-hydroxyphenylglycine
Purity:≥98% (HPLC)
Appearance:White powder.
Solubility:Soluble in dilute aqueous base.
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
(S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors in different brain regions of the neonatal rat: A.I. Sacaan, et al.; Neurochem. Int. 32, 77 (1998), Abstract;
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996), Abstract;
Metabotropic receptors in excitotoxicity: (S)-4-carboxy-3- hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions: L.R. Orlando, et al.; Neurosci. Lett. 202, 109 (1995), Abstract;
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes: A.E. Kingston, et al.; Neuropharmacology 34, 887 (1995), Abstract;
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family: C. Thomsen, et al.; Eur. J. Pharmacol. 267, 77 (1994), Abstract;
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review), Abstract;
The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4- carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia: T. Opitz, et al.; Neuropharmacology 33, 715 (1994), Abstract;
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system: E.F. Birse, et al.; Neuroscience 52, 481 (1993), Abstract;

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