NMDA receptor antagonist acting at the glycine site. More potent than the corresponding kynurenic acid analog (7-Chlorokynurenic acid . hydrochloride).
Product Details
| Alternative Name: | 7-Chloro-4-mercaptoquinoline-2-carboxylic acid . HCl |
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| Formula: | C10H6ClNO2S . HCl |
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| MW: | 239.7 . 36.5 |
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| CAS: | 135025-56-8 |
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| Purity: | ≥99% |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil: D.E. Pellegrini-Giampietro, et al.; Neuroscience
63, 701 (1994),
Abstract;
A study of the dose dependency of a glycine receptor antagonist in focal ischemia: J. Chen, et al.; J. Pharmacol. Exp. Ther.
267, 937 (1993),
Abstract;
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor: F. Moroni, et al.; Eur. J. Pharmacol.
199, 227 (1991),
Abstract;
