Metabolite of tryptophan. Antagonist at both the NMDA and AMPA/kainate receptors. Blocks kainic acid neurotoxicity.
Product Specification
| Alternative Name: | 4-Hydroxyquinoline-2-carboxylic acid |
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| Formula: | C10H7NO3 |
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| MW: | 189.2 |
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| CAS: | 492-27-3 |
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| MI: | 14: 5327 |
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| Purity: | ≥98% (Titration, HPLC) |
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| Appearance: | Off-white to tan powder. |
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| Solubility: | Soluble in 1M NaOH (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solutions are stable for several days when stored at +4°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev.
10, 55 (1990),
Abstract;
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons: M.J. Peet, et al.; Neuroscience
22, 563 (1987),
Abstract;
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid: M.N. Perkins & T.W. Stone; Brain Res.
247, 184 (1982),
Abstract;
