Most potent and selective AMPA/kainate receptor antagonist. For the more soluble form see NBQX . disodium salt (Prod. No. ALX-550-272).
Product Details
| Alternative Name: | 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo(f)-quinoxaline, 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione |
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| Formula: | C12H8N4O6S |
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| MW: | 336.3 |
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| CAS: | 118876-58-7 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Yellow crystalline powder. |
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| Solubility: | Soluble in DMSO. A 1mM aqueous solution may be prepared by taking up in >2.5 eq. of NaOH and backtitrating to pH 8.0-8.5 with conc. HCl. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Emerging treatments for stroke in humans: W.J. Koroshetz & M.A. Moskowitz; TIPS
17, 227 (1996), (Review),
Abstract;
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline: H. Bernert & L. Turski; PNAS
93, 5235 (1996),
Abstract;
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy: T. Namba, et al.; Brain Res.
638, 36 (1994),
Abstract;
A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro: P. Pook, et al.; Br. J. Pharmacol.
108, 179 (1993),
Abstract;
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?: A.M. Buchan, et al.; Stroke
24, I148 (1993),
Abstract;
The pharmacology of AMPA receptors and their antagonists: M.J. Sheardown; Stroke
24, I146 (1993),
Abstract;
Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution: J.C. Randle, et al.; Eur. J. Pharmacol.
215, 237 (1992),
Abstract;
The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl- benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model: R. Gill, et al.; Brain Res.
580, 35 (1992),
Abstract;
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia: M.J. Sheardown, et al.; Science
247, 571 (1990),
Abstract;
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Muller, et al.; Science
242, 1694 (1988),
Abstract;
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