Replaces Prod. #: BML-EA102
Selective agonist for group III mGluRs. NMDA agonist. Potent synaptic depressant.
Product Details
| Alternative Name: | L(+)-2-Amino-4-phosphonobutanoic acid |
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| Formula: | C4H10NO5P |
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| MW: | 183.1 |
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| CAS: | 23052-81-5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White crystalline powder. |
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| Solubility: | Soluble in dilute aqueous base. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology
38, 1431 (1999), (Review),
Abstract;
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate: Y. Nakajima, et al.; J. Biol. Chem.
268, 11868 (1993),
Abstract;
Full Text
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase: C. Thomsen, et al.; Eur. J. Pharmacol.
227, 361 (1992),
Abstract;
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor: P.Q. Trombley and G.L. Westbrook; J. Neurosci.
12, 2043 (1992),
Abstract;
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS
11, 25 (1990),
Abstract;
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res.
235, 378 (1982),
Abstract;
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol.
75, 65 (1982),
Abstract;
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex: J.F. Koerner & C.W. Cotman; Brain Res.
216, 192 (1981),
Abstract;
