Shows sequence similarity with proteasome components and is also being referred to as 26A proteasome regulatory subunit S5A. Shows both matrix and cytoplasmic distribution. It binds to thrombospondin-1 and α2β1 integrin, and it inhibits tumor progression and angiogenesis. Expressed in various types of cancer, such as hepatocellular carcinoma, prostate, lung, bladder and melanoma cancers.
Product Details
| Alternative Name: | 26S proteasome regulatory subunit S5A, 26S proteasome non-ATPase regulatory subunit 4, Rpn10, Multiubiquitin chain-binding protein, Antisecretory factor 1 |
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| MW: | ~50kDa (SDS-PAGE). |
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| Source: | Produced in E. coli. Human Angiocidin (aa 2-377) is untagged. |
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| UniProt ID: | O43242 |
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| Concentration: | 0.1mg/ml after reconstitution. |
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| Formulation: | Lyophilized. Contains PBS. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Lonza). |
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| Reconstitution: | Reconstitute with 100µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor: A. Gaurnier-Hausser & G. P. Tuszynski; Curr. Pharm. Des.
15, 1937 (2009),
Abstract;
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1: J. Zhou, et al.; J. Cell. Biochem.
92, 125 (2004),
Abstract;
