| Alternative Name: | Dendritic cell-associated lectin 2 |
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| MW: | ~55kDa (SDS-PAGE) |
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| Source: | Produced in HEK 293 cells. The extracellular domain of dectin-2 (aa 44-209) is fused at the N-terminus to the Fc portion of human IgG1. |
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| UniProt ID: | Q9JKF4 |
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| Concentration: | 1mg/ml after reconstitution. |
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| Formulation: | Lyophilized. Contains PBS. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Associates of CAPE COD Inc.). |
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| Reconstitution: | Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Scientific Background: | Dectin-2 (dendritic cell-associated C-type lectin-2) is a lectin that has been reported to bind to zymosan as well as to hyphae of organisms such as Candida albicans. Dectin-2 exhibits specific recognition of high-mannose structures. Activation of Dectin-2 leads to phosphorylation of FcRg and up-regulated secretion of TNF-α and IL-1ra. Dectin-2 might act on inflammatory macrophages and DC to detect pathogenic organisms and possibly endogenous glycoproteins. |
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| Regulatory Status: | RUO - Research Use Only |
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