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Thy-1 (human):Fc (human), (recombinant)

ALX-522-091-C050 50 µg 568.00 USD
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Product Details

Alternative Name:CD90
Source:Produced in HEK 293 cells. The extracellular domain of human Thy-1 (aa 20-130) is fused to the Fc portion of human IgG1.
UniProt ID:P04216
Concentration:1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥90% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution:Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:Human Thy-1 is a glycosyl phosphatidylinositol (GPI)- anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation. Historical results have shown that human Thy-1 binds to human αvβ3 integrin.
Regulatory Status:RUO - Research Use Only
Thy-1 (human):Fc (human), (recombinant) SDS-PAGE
SDS-PAGE analysis of Prod. No. ALX-522-091: Lane 1: MW marker, Lane 2: 0.1, Lane 3: 0.5, Labe 4: 1 µg Thy-1 (human):Fc (human), (recombinant).
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Thy-1 (human):Fc (human), (recombinant) SDS-PAGE

Product Literature References

Effect of the GPI anchor of human Thy-1 on antibody recognition and function: J.E. Bradley, et al.; Lab. Invest. 93, 365 (2013), Abstract; Full Text
Thy-1-Integrin {alpha}vβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation: Y. Zhou, et al.; J. Biol. Chem. 285, 22382 (2010), Abstract; Full Text

General Literature References

Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005), Abstract;
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004), Abstract;
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites: L. Leyton, et al.; Curr. Biol. 11, 1028 (2001), Abstract;

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