Product Specification
| Alternative Name: | TLR4, CD284 |
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| MW: | ~83kDa (SDS-PAGE). |
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| Source: | Produced in HEK 293 cells. The N-terminal region of the extracellular domain of mouse TLR4 (aa 24-334) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa). |
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| UniProt ID: | Q9QUK6, Q8K2T5 |
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| GenBank ID: | AAH29856 |
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| Concentration: | 1mg/ml after reconstitution. |
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| Formulation: | Lyophilized. Contains PBS. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
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| Reconstitution: | Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides: H. Li, et al.; Int. J. Biol. Macromol.
72, 649 (2015),
Abstract;
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy: L. Apetoh, et al.; Nat. Med.
13, 1050 (2007),
Abstract;
General Literature References
TLR4 as the mammalian endotoxin sensor: B. Beutler; Curr. Top. Microbiol. Immunol.
270, 109 (2002), (Review),
Abstract;
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction: J.C. Chow, et al.; J. Biol. Chem.
274, 10689 (1999),
Abstract;
Full Text
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene: A. Poltorak, et al.; Science
282, 2085 (1998),
Abstract;
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region: A. Poltorak, et al.; Blood Cells Mol. Dis.
24, 340 (1998),
Abstract;
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