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CD27 (human):Fc (human), (recombinant)

ALX-522-029-C050 50 µg Inquire for pricing
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Product Details

Alternative Name:TNFRSF 7, CD27L receptor, T-cell activation antigen CD27
MW:~55kDa (SDS-PAGE).
Source:Produced in HEK 293 cells. The cysteine-rich region of human CD27 (aa 1-191) is fused to the Fc portion of human IgG1.
UniProt ID:P26842
Concentration:1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity Detail:Purified by single-step affinity chromatography.
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Associates of Cape Cod).
Species reactivity:Human, Mouse
Specificity:Binds human and mouse CD70 (CD27L).
Application Notes:ELISA: binds to CD27L at 1-10 ng/ml.
Can be used together with anti-human IgG1 PAb to detect membrane-bound human and mouse CD70.
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:The CD27 receptor (CD27, Tp55) is a member of the tumor necrosis factor receptor (TNF-R) family. CD27 is a type I transmembrane receptor, it contains 3 extracellular cysteine-rich motifs. CD27 is mainly expressed on T and B lymphocytes, and its expression is increased on T cells by the engagement of the T cell receptor complex. Engagement of CD27 induces recruitment of TNF receptor-associated factor 2 (TRAF2) and TRAF3. CD27-CD70 have been reported to be involved in several different immune mechanisms such as T, NK and B lymphocytes interactions and costimulation, early thymic differentiation, autoimmune and viral diseases and apoptosis.
Regulatory Status:RUO - Research Use Only

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