Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

TNF-R1 (human):Fc (human), (recombinant)

ALX-522-013-C050 50 µg 529.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:p55, CD120a, TNF-R 60kDa, TNFRSF 1A
MW:~60kDa (reducing SDS-PAGE).
Source:Produced in HEK 293 cells. The extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1.
UniProt ID:P19438
Concentration:1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Species reactivity:Human, Mouse
Specificity:Binds human and mouse TNF-α (tumor necrosis factor-a).
Application Notes:ELISA: binds to TNF-α.
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Technical Info/Product Notes:Previous data has shown that TNF-R1 receptor binds to TNF-R1 and triggers various biological effects (including cell death). rhTNF-R1:Fc fusion protein blocks TNF-α-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml using Wehi cells.
Regulatory Status:RUO - Research Use Only
TNF-R1 (human):Fc (human), (recombinant) image
Figure: Inhibition of TNF-mediated lysis of WEHI 164 target cells (rhsTNF-a, Prod. No. ALX-522-008). rhTNF-R1:Fc exerts its inhibitory activity in a concentration range of 10-50ng/ml."
Please mouse over
TNF-R1 (human):Fc (human), (recombinant) image

Product Literature References

Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol: C.T. Hellwig, et al.; Cell Death Differ. 29, 147 (2022), Abstract;
TNF-α and IFN-γ are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis: I. Viard-Leveugle, et al.; J. Invest. Dermatol. 133, 489 (2013), Application(s): Flow cytometry analysis of NO production in mammalian cells, Abstract;
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract;
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract;
The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells: I.A. Rooney, et al.; J. Biol. Chem. 275, 13047 (2000), Abstract; Full Text

Related Products

Control:Fc fusion protein (human), (recombinant) 

Negative control for Fc chimeric proteins
Produced in HEK 293 cells. The extracellular domain of mutated hThy-1, hThy-1 (RLE) (aa 20-130), is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of hThy-1 has been changed to RLE abolishing the binding of integrins., ≥90% (SDS-PAGE) | Print as PDF
ALX-203-004-C050 50 µg 532.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
TNF receptor
By biological activity:
TNF receptor Recombinant protein
By catalog section:


Technical Service
Customer Service