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United States 

IL-1β (human), (recombinant) (cell culture grade)

Potent immunomodulator
ALX-520-001-C010 10 µg 490.00 USD
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Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.

Product Details

Alternative Name:IL-1F2, Interleukin-1β
Source:Produced in E. coli.
MI:14: 4993
UniProt ID:P01584
Formulation:Lyophilized. Salt-free.
Purity:≥97% (SDS-PAGE)
Endotoxin Content:<1EU/µg protein.
Biological Activity:Exerts in vitro biological activity in the range of 0.1-10ng/ml.
Specific Activity:≥1x107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC).
Reconstitution:Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Regulatory Status:RUO - Research Use Only

Product Literature References

An unexpected effect of TNF-α on F508del-CFTR maturation and function: S. Bitam, et al.; F1000Res 4, 218 (2015), Abstract; Full Text
Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion: J.Y. Yang, et al.; J. Biol. Chem. 280, 32835 (2005), Abstract;

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