Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
Product Details
| Alternative Name: | IL-1F2, Interleukin-1β |
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| MW: | ~17kDa. |
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| Source: | Produced in E. coli. |
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| CAS: | 97599-21-8 |
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| MI: | 14: 4993 |
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| UniProt ID: | P01584 |
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| Formulation: | Lyophilized. Salt-free. |
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| Purity: | ≥97% (SDS-PAGE) |
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| Endotoxin Content: | <1EU/µg protein. |
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| Biological Activity: | Exerts in vitro biological activity in the range of 0.1-10ng/ml. |
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| Specific Activity: | ≥1x107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC). |
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| Reconstitution: | Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
An unexpected effect of TNF-α on F508del-CFTR maturation and function: S. Bitam, et al.; F1000Res
4, 218 (2015),
Abstract;
Full Text
Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion: J.Y. Yang, et al.; J. Biol. Chem.
280, 32835 (2005),
Abstract;
