OTG is a nonionic detergent that may be used to isolate membrane proteins from E. coli without inactivation. Stable in aqueous solution and easily removed by dialysis.
Product Details
| Alternative Name: | n-Octyl-β-D-thioglucoside, OTG |
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| Formula: | C14H28O5S |
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| MW: | 308.4 |
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| CAS: | 85618-21-9 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in water (8g/100ml) or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of mixed non-ionic surfactants n-octyl-beta-D-thioglucoside and octaethylene-glycol monododecyl ether: micellization and microstructure: C.C. Ruiz & J.A. Molina-Bolivar; J. Colloid. Interface Sci.
361, 178 (2011),
Abstract;
Solubilization and structural stability of bacteriorhodopsin with a mild nonionic detergent, n-Octyl-beta-thioglucoside: A. Asada, & M. Sonoyama; Biosci. Biotechnol. Biochem.
75, 376 (2011),
Abstract;
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Development and crystallization of a minimal thermostabilised G protein-coupled receptor: T. Warne, et al.; Protein Expr. Purif.
65, 204 (2009),
Abstract;
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state: S. Ravaud, et al.; Biochem. J.
395, 345 (2006),
Abstract;
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Use of n-Octyl-β-D-thioglucopyranoside in the isolation of a bacterial membrane protein: an improved method for immunological applications.: J.M. Peula-Garcia, et al.; J. Surface Sci. Technol.
22, 141 (2006),
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Use of octyl beta-thioglucopyranoside in two-dimensional crystallization of membrane proteins: M. Chami, et al.; J. Struct. Biol.
133, 64 (2001),
Abstract;
Characteristics of n-octyl beta-D-thioglucopyranoside, a new non-ionic detergent useful for membrane biochemistry: S. Saito & T. Tsuchiya; Biochem. J.
222, 829 (1984),
Abstract;
Use of n-octyl-beta-D-thioglucoside, a new nonionic detergent, for solubilization and reconstitution of membrane proteins: T. Tsuchiya & S. Saito; J. Biochem.
96, 1593 (1984),
Abstract;
