Prodrug converted to the free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as the 5'-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells. Inhibits RNA transcription.
Product Details
| Alternative Name: | 2-Fluoroadenine-9-β-D-arabinofuranoside |
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| Formula: | C10H12FN5O4 |
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| MW: | 285.2 |
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| CAS: | 21679-14-1 |
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| MI: | 14: 4126 |
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| RTECS: | AU6207000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to pale yellow crystalline powder. |
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| Solubility: | Sparingly soluble in water or organic solvents. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity: P. Huang, et al.; J. Biol. Chem.
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