Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.
Product Details
| Alternative Name: | 5-FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
| |
| Formula: | C4H3FN2O2 |
| |
| MW: | 130.1 |
| |
| CAS: | 51-21-8 |
| |
| MI: | 14: 4181 |
| |
| RTECS: | YR0350000 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Identity: | Determined by IR. |
| |
| Appearance: | White to off-white crystalline powder. |
| |
| Solubility: | Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita: H. Tummala, et al.; Am. J. Hum. Genet.
109, 1472 (2022),
Abstract;
A selective p53 activator and anticancer agent to improve colorectal cancer therapy: H. Ramos, et al.; Cell Rep.
35, 108982 (2021),
Abstract;
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res.
34, 152 (2015),
Application(s): Cell culture,
Abstract;
Full Text
5-fluorouracil sensitivity and dihydropyrimidine dehydrogenase activity in advanced gastric cancer: T. Inada, et al.; Anticancer Res.
20, 2457 (2000),
Abstract;
Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line: H. Takeda, et al.; Jpn. J. Cancer Res.
90, 677 (1999),
Abstract;
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity: D.M. Pritchard, et al.; Toxicol. Lett.
102, 19 (1998),
Abstract;
Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells: S. Wadler, et al.; Biochem. Pharmacol.
55, 1353 (1998),
Abstract;
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells: K.H. Elstein, et al.; Toxicol. Appl. Pharmacol.
146, 29 (1997),
Abstract;
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis: J. Pressacco, et al.; Br. J. Cancer
72, 939 (1995),
Abstract;
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res.
14, 1027 (1994),
Abstract;
