Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.
Product Details
| Alternative Name: | 5-FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
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| Formula: | C4H3FN2O2 |
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| MW: | 130.1 |
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| CAS: | 51-21-8 |
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| MI: | 14: 4181 |
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| RTECS: | YR0350000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita: H. Tummala, et al.; Am. J. Hum. Genet.
109, 1472 (2022),
Abstract;
A selective p53 activator and anticancer agent to improve colorectal cancer therapy: H. Ramos, et al.; Cell Rep.
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Abstract;
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res.
34, 152 (2015),
Application(s): Cell culture,
Abstract;
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Abstract;
Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line: H. Takeda, et al.; Jpn. J. Cancer Res.
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Abstract;
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity: D.M. Pritchard, et al.; Toxicol. Lett.
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Abstract;
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Abstract;
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells: K.H. Elstein, et al.; Toxicol. Appl. Pharmacol.
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Abstract;
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis: J. Pressacco, et al.; Br. J. Cancer
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Abstract;
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res.
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Abstract;
