Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.
Product Details
Alternative Name: | 5-FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
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Formula: | C4H3FN2O2 |
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MW: | 130.1 |
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CAS: | 51-21-8 |
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MI: | 14: 4181 |
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RTECS: | YR0350000 |
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Purity: | ≥98% (HPLC) |
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Identity: | Determined by IR. |
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Appearance: | White to off-white crystalline powder. |
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Solubility: | Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml). |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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109, 1472 (2022),
Abstract;
A selective p53 activator and anticancer agent to improve colorectal cancer therapy: H. Ramos, et al.; Cell Rep.
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Abstract;
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res.
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Application(s): Cell culture,
Abstract;
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Abstract;
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Abstract;
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Abstract;