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8-Hydroxy-2'-deoxyguanosine

 
ALX-480-090-M001 1 mg 88.00 USD
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Oxidative DNA degradation product.

Product Details

Alternative Name:8-OHdG
 
Formula:C10H13N5O5
 
MW:283.2
 
CAS:88847-89-6
 
Purity:≥98%
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (15mg/ml) or DMSO (12mg/ml).
 
Shipping:Ambient Temperature
 
Long Term Storage:Ambient
 
Regulatory Status:RUO - Research Use Only
 
ALX-480-090
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ALX-480-090

Product Literature References

Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine: K. Asagoshi, et al.; J. Biol. Chem. 275, 4956 (2000), Abstract; Full Text
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells: E. Cappelli, et al.; Biochemistry 39, 10408 (2000), Abstract;
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements: M.S. Cooke, et al.; Free Radic. Res. 32, 381 (2000), Abstract;
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol. 9, 133 (1999), Abstract;
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994), Abstract;
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column: E.M. Park, et al.; PNAS 89, 3375 (1992), Abstract;
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985), Abstract;

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