Oxidative DNA degradation product.
Product Details
| Alternative Name: | 8-OHdG |
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| Formula: | C10H13N5O5 |
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| MW: | 283.2 |
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| CAS: | 88847-89-6 |
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| Purity: | ≥98% |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (15mg/ml) or DMSO (12mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine: K. Asagoshi, et al.; J. Biol. Chem.
275, 4956 (2000),
Abstract;
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Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells: E. Cappelli, et al.; Biochemistry
39, 10408 (2000),
Abstract;
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements: M.S. Cooke, et al.; Free Radic. Res.
32, 381 (2000),
Abstract;
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol.
9, 133 (1999),
Abstract;
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol.
234, 16 (1994),
Abstract;
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column: E.M. Park, et al.; PNAS
89, 3375 (1992),
Abstract;
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem.
28, 1194 (1985),
Abstract;
