Replaces Prod. #: BML-G300
Cell impermeable, non-hydrolyzable analog of guanosine 5'-O-diphosphate (GDP) that competitively inhibits G-protein activation by GTP and GTP analogs. Use at concentrations similar to GTP-γ-S (Prod. No. ALX-480-056) (50 µM).
Product Details
| Alternative Name: | GDP-β-S . 3Li |
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| Formula: | C10H12N5O10P2S . 3Li |
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| MW: | 456.2 . 20.8 |
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| CAS: | 97952-36-8 |
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| Purity: | ≥85% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. Unstable at room temperature. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus: N. Equchi, et al.; Neurosci. Lett.
616, 170 (2016),
Application(s): Cell culture,
Abstract;
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes: S.T. Silk, et al.; J. Biol. Chem.
264, 21466 (1989),
Abstract;
Full Text
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2: R.M. Burch & J. Axelrod; PNAS
84, 6374 (1987),
Abstract;
G proteins: transducers of receptor-generated signals: A.G. Gilman, et al.; Annu. Rev. Biochem.
56, 615 (1987), (Review),
Abstract;
General Literature References
ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1: D.M. Gill & J. Coburn; Biochemistry
26, 6364 (1987),
Abstract;
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