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Guanosine 5'-O-(2-thiodiphosphate) . trilithium salt

G protein inhibitor
ALX-480-081-M005 5 mg Inquire for pricing
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Replaces Prod. #: BML-G300

Cell impermeable, non-hydrolyzable analog of guanosine 5'-O-diphosphate (GDP) that competitively inhibits G-protein activation by GTP and GTP analogs. Use at concentrations similar to GTP-γ-S (Prod. No. ALX-480-056) (50 µM).

Product Details

Alternative Name:GDP-β-S . 3Li
Formula:C10H12N5O10P2S . 3Li
MW:456.2 . 20.8
Purity:≥85% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. Unstable at room temperature.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus: N. Equchi, et al.; Neurosci. Lett. 616, 170 (2016), Application(s): Cell culture, Abstract;
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes: S.T. Silk, et al.; J. Biol. Chem. 264, 21466 (1989), Abstract; Full Text
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2: R.M. Burch & J. Axelrod; PNAS 84, 6374 (1987), Abstract;
G proteins: transducers of receptor-generated signals: A.G. Gilman, et al.; Annu. Rev. Biochem. 56, 615 (1987), (Review), Abstract;

General Literature References

ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1: D.M. Gill & J. Coburn; Biochemistry 26, 6364 (1987), Abstract;

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ALX-480-056-M001 1 mg 68.00 USD
ALX-480-056-M005 5 mg 224.00 USD
Do you need bulk/larger quantities?

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