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8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt

PKA inhibitor
ALX-480-024-MC05 0.5 mg 213.00 USD
ALX-480-024-M001 1 mg 325.00 USD
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Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No. BML-CN135, and Prod. No. ALX-480-085). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No. BML-CN115).

Product Details

Alternative Name:Rp-8-Br-cAMPS . Na, 8-Br-cAMPS . Na, Rp-isomer
Formula:C10H10BrN5O5PS . Na
MW:423.2 . 23.0
Purity:≥99% (HPLC)
Identity:Identity determined by MS and UV.
Appearance:White to off-white powder.
Solubility:250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway: G. Mottola, et al.; PLoS One 12, e0174936 (2017), Abstract; Full Text
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture: B.T. Gjertsen, et al.; J. Biol. Chem. 270, 20599 (1995), Abstract; Full Text
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase: A.C. Chao, et al.; EMBO J. 13, 1065 (1994), Abstract;

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