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O6-Benzylguanine

DNA alkyltransferase substrate and inhibitor
 
ALX-480-019-M010 10 mg 56.00 USD
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Effective substrate and efficient inactivator of DNA alkyltransferase.

Product Specification

Formula:C12H11N5O
 
MW:241.2
 
CAS:19916-73-5
 
Purity:≥98% (TLC)
 
Identity:Identity determined by 1H-NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in methanol (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Regulatory Status:RUO - Research Use Only
 
480-019
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480-019

Product Literature References

Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo: E.L. Kreklau, et al.; Pharmacol. Exp. Ther. 291, 1269 (1999), Abstract;
O6-benzylguanine and its role in chemotherapy: M.E. Dolan & A.E. Pegg; Cancer Res. 3, 837 (1997), Abstract;
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA: K. Goodtzova, et al.; Biochemistry 33, 8385 (1994), Abstract;
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine: R.H. Elder, et al.; Biochem. J. 298, 231 (1994), Abstract;

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