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NADPH . tetrasodium salt

ALX-480-004-M050 50 mg 73.00 USD
ALX-480-004-M250 250 mg 243.00 USD
ALX-480-004-G001 1 g 780.00 USD
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NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of ROS (reactive oxygen species), allowing the regeneration of GSH (reduced glutathione). NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.

The NADPH system is also responsible for generating free radicals in immune cells. These radicals are used to destroy pathogens in a process termed the respiratory burst. It is the source of reducing equivalents for cytochrome P450 hydroxylation of aromatic compounds, steroids, alcohols, and drugs.

Product Details

Alternative Name:β-Nicotinamide Adenine Dinucleotide Phosphate (reduced form) . 4Na, β-NADPH . 4Na
Formula:C21H26N7O17P3 . 4Na
MW:741.4 . 92.0
Purity:≥95% (HPLC)
Appearance:White to light yellow powder.
Solubility:Soluble in water (50mg/ml) or 0.01M sodium hydroxide.
Long Term Storage:-20°C
Use/Stability:NADPH is unstable in acid media. Stock solutions should be at pH 8.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Repetitively Hypoxic Preconditioning Attenuates Ischemia/Reperfusion-Induced Liver Dysfunction Through Upregulation of Hypoxia-Induced factor-1 Alpha-Dependent Reversible Oxidative Modifications in Myoglobin and Functional Implications: M.H. Mannino, et al.; Antioxidants (Basel) 9, 549 (2020), Abstract; Full Text
Globular adiponectin attenuates LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling: A. Shrestha & P.H. Park; Life Sci. 148, 71 (2016), Application(s): Cell culture, Abstract;
Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase: M.R. Duff, et al.; Biochemistry 55, 133 (2016), Abstract; Full Text
Efferent and afferent innervation of primate trabecular meshwork and scleral spur: J.M. Selbach, et al.; Invest. Ophthalmol. Vis. Sci. 41, 2184 (2000), Abstract; Full Text

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