NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of ROS (reactive oxygen species), allowing the regeneration of GSH (reduced glutathione). NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.
The NADPH system is also responsible for generating free radicals in immune cells. These radicals are used to destroy pathogens in a process termed the respiratory burst. It is the source of reducing equivalents for cytochrome P450 hydroxylation of aromatic compounds, steroids, alcohols, and drugs.
Product Details
| Alternative Name: | β-Nicotinamide Adenine Dinucleotide Phosphate (reduced form) . 4Na, β-NADPH . 4Na |
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| Formula: | C21H26N7O17P3 . 4Na |
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| MW: | 741.4 . 92.0 |
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| CAS: | 2646-71-1 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to light yellow powder. |
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| Solubility: | Soluble in water (50mg/ml) or 0.01M sodium hydroxide. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | NADPH is unstable in acid media. Stock solutions should be at pH 8. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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