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Heavy metal chelator
ALX-450-011-M100 100 mg 122.00 USD
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Replaces Prod. #: BML-AP300

A cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 (Prod. No. ENZ-52013) or QUIN 2/AM to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Complex with Fe2+ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in T cells.

Product Specification

Alternative Name:N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
Purity:≥97% (Nonaqueous Titration)
Appearance:White to off-white solid.
Solubility:Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells: H.J. Hyun, et al.; Invest. Ophthalmol. Vis. Sci. 42, 460 (2001), Abstract;
Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells: M. Adler, et al.; Neurotoxicology 20, 571 (1999), Abstract;
The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+: S. Jiang et al.; Cell Death Differ. 4, 39 (1997), Abstract;
Chelation of intracellular zinc triggers apoptosis in mature thymocytes: M.J. McCabe, et al.; Lab. Invest. 69, 101 (1993), Abstract;
Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake [published erratum appears in J Biol Chem 1993 Mar 15;268(8):6064]: P.M. Hinkle, et al.; J. Biol. Chem. 267, 25553 (1992), Abstract; Full Text
Mechanism of reaction of a suggested superoxide-dismutase mimic, Fe(II)- N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: L. Iuliano, et al.; Arch. Biochem. Biophys. 293, 153 (1992), Abstract;
TPEN, a transition metal chelator, improves myocardial protection during prolonged ischemia: M. Karck, et al.; J. Heart Lung Transplant 11, 979 (1992), Abstract;
Superoxide dismutase mimics based on iron in vivo: T. Nagano et al.; J. Biol. Chem. 264, 9243 (1989), Abstract;
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+: P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985), Abstract; Full Text
Spin Equilibria in Octahedral Iron(II) Complexes with Some Hexadentate Ligands of the Tetrakis(2-pyridylmethyl)ethylenediamine Type and a Spectral Correlation With Their Cobalt(III) and Nickel(II) Analogs: H. Toftlund & S. Yde-Andersen; Acta Chem. Scand. Ser. A35, 575 (1981), Full Text

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