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Monovalent cation ionophore
ALX-450-008-M005 5 mg 58.00 USD
ALX-450-008-M025 25 mg 236.00 USD
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Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.

Product Details

Alternative Name:Polynactin, Werramycin A
Source:Isolated from Streptomyces griseus.
MI:14: 6675
Purity:≥98% (TLC) (Total homologs)
Purity Detail:Mixture of two homologs (~80% nonactin and ~20% monactin)
Appearance:White to off-white crystalline solid.
Solubility:Soluble in DMSO (10mg/ml), dichloromethane (10mg/ml), methanol, 100% ethanol; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A new potentiometric ammonium electrode for biosensor construction: E. Karakus, et al.; Artif. Cells. Blood Substit. Immobil. Biotechnol. 34, 523 (2006), Abstract;
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane: C.A. Garcia, et al.; J. Pharm. Biomed. Anal. 31, 11 (2003), Abstract;
Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4’-O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells : M.N. Borrel, et al.; Eur. J. Biochem. 223, 125 (1994), Abstract;
Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction: S.N. Graven, et al.; Biochemistry 5, 1729 (1966), Abstract;
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry 5, 1735 (1966), Abstract;
The in vitro activity of nonactin and Its homologs: Monactin, dinactin and trinactin: E. Meyers, et al.; J. Antibiot. 18, 128 (1965), Abstract;
[Antibacterial spectrum of nonactin with special consideration of Corynebacteriaceae]: W. Kohler, et al.; Zentralbl Bakteriol [Orig] 194, 457 (1964), Abstract;

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