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United States 

Ionomycin (free acid)

Calcium ionophore
ALX-450-006-M001 1 mg 114.00 USD
ALX-450-006-M005 5 mg 462.00 USD
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Replaces Prod. #: BML-CA201

Potent and highly selective calcium ionophore. Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase. Useful tool for increasing intracellular Ca2+ concentration. More effective than A23187. Non fluorescent. Has been used at 4nM and 2-4µM  (whole cells).

Product Details

Source:Isolated from Streptomyces conglobatus.
Purity:≥90% (HPLC, TLC)
Appearance:Waxy yellow to colorless material
Solubility:Soluble in DMSO or methanol.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stock solutions are stable for 1 year when stored at +4°C.
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells: C.L. So, et al.; Cell Calcium 104, 102569 (2022), Abstract;
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses: M.E. Cook, et al.; Sci. Immunol. 7, eabo0981 (2022), Abstract;
Up-regulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cell activation in psoriasis: J. Zhou, et al.; PNAS 119, e2117523119 (2022), Abstract;
Evaluation of a combination "lymphocyte apoptosis model" to predict survival of sepsis patients in an intensive care unit: W. Jiang, et al.; BMC Anesthesiol. 18, 89 (2018), Abstract; Full Text
Mesenchymal stem cells induced CD4+ T cell apoptosis in treatment of lupus mice: S. Huang, et al.; Biochem. Biophys. Res. Commun. 507, 30 (2018), Abstract;
Chrysin suppresses human CD14+ monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis: K. Zhang, et al.; J. Neuroimmunol. 288, 13 (2015), Application(s): Intracellular cytokine staining, Abstract;
Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis: K. Rui, et al.; Cell. Mol. Immunol. 13, 401 (2015), Application(s): Flow cytometric analysis in mouse cells, Abstract;
Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats: F. Zhang, et al.; Int. Immunopharmacol. 28, 546 (2015), Application(s): Cell culture , Abstract;
The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations: T. Tian, et al.; PLoS One 10, e0131761 (2015), Application(s): Cell Culture, Abstract; Full Text
Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line: C.H. Park, et al.; Carcinogenesis 26, 1929 (2005), Abstract;
ctivation of stress response by ionomycin in rat hepatoma cells: A. S. Sreedhar & U. K. Srinivas; J. Cell. Biochem. 86, 154 (2002), Abstract;
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation: K. Brown, et al.; Science 267, 1485 (1995), Abstract;
Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery & D.F. Jelinek; J. Immunol. 155, 3297 (1995), Abstract;
Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res. 652, 65 (1994), Abstract;
Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d'Angeac, et al.; J. Cell. Physiol. 154, 44 (1993), Abstract;
Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose: H.C. Lee; J. Biol. Chem. 268, 293 (1993), Abstract; Full Text
Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol: G. Kuznetsov, et al.; J. Biol. Chem. 267, 3932 (1992), Abstract; Full Text
Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions: B.K. Toeplitz at al.; JACS 101, 3344 (1979),
Characterization of ionomycin as a calcium ionophore: C.M. Liu & T.E. Herman; J. Biol. Chem. 253, 5892 (1978), Abstract; Full Text

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