Replaces Prod. #: BML-CN250
Cofactor of nitric oxide synthases (NOS).
Product Details
| Alternative Name: | (6R)-BH4 . 2HCl, [6R-[6R*(1R*,2S*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone . 2HCl, Sapropterin . dihydrochloride |
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| Formula: | C9H15N5O3 . 2HCl |
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| MW: | 314.2 |
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| CAS: | 69056-38-8 |
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| MI: | 14: 8368 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for several years when stored at -20°C.
Sensitive to oxidation, especially in neutral and alkaline solutions. Solutions must be stored at -20°C or colder immediately after preparation. Use oxygen free water with the lowest possible pH. Ascorbic acid, DTT, or other antioxidants may be added in order to increase stability. |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protective effects of (6R) 5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion induced suppression of reactive hyperemia in rat gingiva: Y. Tanaka, et al. ; J. Clin. Biochem. Nutr.
58, 69 (2015),
Abstract;
Full Text
Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages: N. Sakai and S. Milstien; BBRC
193, 378 (1993),
Abstract;
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem.
268, 1842 (1993),
Abstract;
Full Text
Regulation of the L-arginine-dependent and tetrahydrobiopterin- dependent biosynthesis of nitric oxide in murine macrophages: G. Schoedon, et al.; Eur. J. Biochem.
213, 833 (1993),
Abstract;
Tetrahydrobiopterin and cytokines: E.R. Werner, et al.; Proc. Soc. Exp. Biol. Med.
203, 1 (1993), (Review),
Abstract;
Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity: J.M. Hevel & M.A. Marletta; Biochemistry
31, 7160 (1992),
Abstract;
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry
31, 6822 (1992),
Abstract;
Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor: P. Klatt, et al.; FEBS Lett.
305, 160 (1992),
Abstract;
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem.
267, 25722 (1992),
Abstract;
Full Text
Brain nitric oxide synthase is a biopterin- and flavin-containing multi- functional oxido-reductase: B. Mayer, et al.; FEBS Lett.
288, 187 (1991),
Abstract;
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells: J.S. Pollock, et al.; PNAS
88, 10480 (1991),
Abstract;
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine: J. Giovanelli, et al.; PNAS
88, 7091 (1991),
Abstract;
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages: N.S. Kwon et al.; J. Biol. Chem.
264, 20496 (1989),
Abstract;
