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Necrox-5™ . hydrochloride

Necrosis inhibitor
ALX-430-247-M001 1 mg 194.00 USD
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Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Product Details

Alternative Name:[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine
Formula:C25H31N3O3S . 2 HCl
MW:453.6 . 72.9
Purity:≥96% (HPLC, TLC)
Identity:Determined by LC-MS.
Appearance:Yellow solid.
Solubility:Soluble in DMSO (>10mg/ml).
Application Notes:Can be used for in vitro and in vivo applications.
For in vitro experiments, dissolve Necrox-5™ in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30μM to 0.1μM final concentration.
For in vivo experiments, dissolve the product in DMSO at a concentration of 10mg/ml stock. Do not use PBS and Water!
Optimal conditions must be determined individually for each application.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
ALX-430-247 structure
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Product Literature References

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: K. Min, et al.; Cancers (Basel) 12, 3388 (2020), Abstract;
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol. 106, 749 (2011), Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res. 33, 1813 (2010), Abstract;

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