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mito-TEMPO-H

Spin probe
 
ALX-430-171-M005 5 mg 78.00 USD
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Spin probe for detection of mitochondrial superoxide.
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.

Product Specification

Alternative Name:1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine, 1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido]piperidinium dichloride
 
Formula:C29H37N2O2Cl2P . H2O
 
MW:511.1 . 18.0
 
Purity:≥95% (EPR)
 
Appearance:Colorless to pink.
 
Solubility:Soluble in water, 100% ethanol or methanol.
 
Application Notes:Mito-TEMPO-H can be used for superoxide detection.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted: E. Korhonen, et al.; FASEB J. (2020), Abstract; Full Text
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. e58461 (2019), Abstract;
Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response: H. Liu, et al.; Cardiovasc. Res. 103, 131 (2014), Abstract; Full Text
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res. 45, 417 (2011), Abstract;
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract;

General Literature References

Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol. 47, 629 (2007), Review, Abstract;

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