Spin probe for detection of mitochondrial superoxide.
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.
Product Details
| Alternative Name: | 1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine, 1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido]piperidinium dichloride |
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| Formula: | C29H37N2O2Cl2P . H2O |
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| MW: | 511.1 . 18.0 |
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| Purity: | ≥95% (EPR) |
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| Appearance: | Colorless to pink. |
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| Solubility: | Soluble in water, 100% ethanol or methanol. |
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| Application Notes: | Mito-TEMPO-H can be used for superoxide detection. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted: E. Korhonen, et al.; FASEB J.
34, 6437 (2020),
Abstract;
Full Text
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. e58461 (2019),
Abstract;
Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response: H. Liu, et al.; Cardiovasc. Res.
103, 131 (2014),
Abstract;
Full Text
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res.
45, 417 (2011),
Abstract;
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res.
107, 106 (2010),
Abstract;
General Literature References
Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol.
47, 629 (2007), Review,
Abstract;
