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Spin probe
ALX-430-171-M005 5 mg Inquire for pricing
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Spin probe for detection of mitochondrial superoxide.
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.

Product Details

Alternative Name:1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine, 1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido]piperidinium dichloride
Formula:C29H37N2O2Cl2P . H2O
MW:511.1 . 18.0
Purity:≥95% (EPR)
Appearance:Colorless to pink.
Solubility:Soluble in water, 100% ethanol or methanol.
Application Notes:Mito-TEMPO-H can be used for superoxide detection.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action: B.M. Pharoah, et al.; Redox Biol. 60, 102625 (2023), Abstract;
Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted: E. Korhonen, et al.; FASEB J. 34, 6437 (2020), Abstract; Full Text
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. e58461 (2019), Abstract;
Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response: H. Liu, et al.; Cardiovasc. Res. 103, 131 (2014), Abstract; Full Text
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res. 45, 417 (2011), Abstract;
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract;

General Literature References

Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol. 47, 629 (2007), Review, Abstract;

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