Necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 (Nec-1 to -5), as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in the pathway.
Product Details
| Formula: | C16H10N5OS2F |
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| MW: | 371.4 |
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| CAS: | 351062-08-3 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Keep cool and dry. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Retinal pigment epithelial cell necroptosis in response to sodium iodate: J. Hanus, et al.; Cell Death Discov.
2, 16054 (2016),
Application(s): Cell culture, transfection, treatments, and MTT assay (human cells),
Abstract;
Full Text
Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7: W. Zheng, et al.; Bioorg. Med. Chem. Lett.
18, 4932 (2008),
Abstract;
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