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United States 

GYY 4137

H2S donor
ALX-430-163-M010 10 mg 75.00 USD
ALX-430-163-M050 50 mg 319.00 USD
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Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.

Product Details

Alternative Name:4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
Formula:C11H15NO2PS2 . C4H10NO
MW:288.3 . 88.1
Identity:Identity determined by 1H-NMR.
Appearance:White solid.
Solubility:Soluble in water (30mg/ml) or DMSO (15mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide: Q.C. Yong, et al.; Antioxid. Redox Signal. 14, 2081 (2011), Abstract;
The slow releasing H2S donor GYY 4137 exerts anti-thrombotic effects via a P-selectin dependent mechanism: E. Grambow, et al.; DGCH (2011), Abstract;
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo: Z.W. Lee, et al.; PLoS One 6, e21077 (2011), Abstract; Full Text
A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation: M. Lisjak, et al.; Plant Physiol. Biochem. 48, 931 (2010), Abstract;
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages: M. Whiteman, et al.; Antioxid. Redox Signal. 12, 1147 (2010), Abstract; Full Text
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.: L. Li, et al.; Free Radic. Biol. Med. 47, 103 (2009), Abstract;
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.: L. Li et, al.; Circulation 117, 2351 (2008), Abstract; Full Text