Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
Product Details
| Alternative Name: | 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt |
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| Formula: | C11H15NO2PS2 . C4H10NO |
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| MW: | 288.3 . 88.1 |
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| Source: | Synthetic. |
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| CAS: | 106740-09-4 |
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| Purity: | ≥95% |
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| Identity: | Identity determined by 1H-NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (30mg/ml) or DMSO (15mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide: Q.C. Yong, et al.; Antioxid. Redox Signal.
14, 2081 (2011),
Abstract;
The slow releasing H2S donor GYY 4137 exerts anti-thrombotic effects via a P-selectin dependent mechanism: E. Grambow, et al.; DGCH (2011),
Abstract;
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo: Z.W. Lee, et al.; PLoS One
6, e21077 (2011),
Abstract;
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A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation: M. Lisjak, et al.; Plant Physiol. Biochem.
48, 931 (2010),
Abstract;
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages: M. Whiteman, et al.; Antioxid. Redox Signal.
12, 1147 (2010),
Abstract;
Full Text
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.: L. Li, et al.; Free Radic. Biol. Med.
47, 103 (2009),
Abstract;
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.: L. Li et, al.; Circulation
117, 2351 (2008),
Abstract;
Full Text
