Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).
Product Details
| Alternative Name: | α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid |
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| Formula: | C18H12Cl2N4O4S |
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| MW: | 451.3 |
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| CAS: | 315706-13-9 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Determined by MS, IR. |
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| Appearance: | Brown solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR: S. Ivanov & C. Roy; Nat. Immunol.
14, 1219 (2013),
Application(s): Analysis of mouse macrophages by WB, PCR,
Abstract;
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Spinal protein kinase M zeta underlies the maintenance mechanism of persistent nociceptive sensitization: M.N. Asiedu, et al.; J. Neurosci.
31, 6646 (2011),
Abstract;
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BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis: F. Grespi, et al.; Cell Death Differ.
17, 1672 (2010),
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IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex: O.K. Melemedjian, et al.; J. Neurosci.
30, 15113 (2010),
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The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation: S. Fan, et al.; Neoplasia
12, 346 (2010),
Abstract;
Uncoupling stress granule assembly and translation initiation inhibition: S. Mokas, et al.; Mol. Biol. Cell
20, 2673 (2009),
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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G: N.J. Moerke, et al.; Cell
128, 257 (2007),
Abstract;
