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Inhibitor of p53/HDM2 interaction
ALX-430-151-M001 1 mg 107.00 USD
ALX-430-151-M005 5 mg 549.00 USD
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Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53.

Product Details

Alternative Name:Reactivation of p53 and Induction of Tumor Cell Apoptosis, 2,5-bis(5-Hydroxymethyl-2-thienyl)furan, NSC652287
Purity:≥98% (HPLC)
Appearance:White to brown crystalline solid.
Solubility:Soluble in 100% ethanol (1mg/ml), DMSO (20mg/ml), dimethyl formamide (30mg/ml); 0.5mg/ml soluble in a 1:1 solution of dimethyl formamide: PBS (pH 7.2) (dissolve RITA first in dimethyl formamide and then dilute with PBS).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least two years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Regulatory Status:RUO - Research Use Only
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Product Literature References

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro: M. Krajewski, et al.; Nat. Med. 11, 1135 (2005), Abstract;
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors: N. Issaeva, et al.; Nat. Med. 10, 1321 (2004), Abstract;
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells: W. Nieves-Neira, et al.; Mol. Pharmacol. 56, 478 (1999), Abstract; Full Text
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism: M.I. Rivera, et al.; Biochem. Pharmacol. 57, 1283 (1999), Abstract;

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