Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.
Product Details
| Alternative Name: | (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride |
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| Formula: | C29H35N2O2ClP |
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| MW: | 510.03 |
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| CAS: | 1334850-99-5 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Determined by MS. |
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| Appearance: | Colorless film to pale orange solid. |
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| Solubility: | Soluble in water, DMSO, 100% ethanol or methanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions in water, saline, ethanol or DMSO are stable at +4°C for 1-2 weeks. DMSO stock solution can be stored also at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Aldosterone Suppresses Endothelial Mitochondria through Mineralocorticoid Receptor/Mitochondrial Reactive Oxygen Species Pathway: S.Y. Peng, et al.; Biomedicines
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Protective role of hydrogen sulfide against diabetic cardiomyopathy via alleviating necroptosis: W. Gong, et al.; Free Radic. Biol. Med.
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Targeting mitochondrial permeability transition pore ameliorates PM 2.5-induced mitochondrial dysfunction in airway epithelial cells: Y. Liang, et al.; Environ. Pollut.
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Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome: L.Q. Wang, et al.; Nat. Commun.
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CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction: E. Aplak, et al.; PLoS One
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Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress: M. Sonavane, et al.; PLoS One
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MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation: J. Zheng, et al.; Cell Death Dis.
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Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics: J. Nomura, et al.; Sci. Rep.
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Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells: F. De Santis, et al.; PLoS One
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ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation: E. Park, et al.; Cell Death Dis.
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Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease: G. Renga, et al.; Life Sci. Alliance
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Mitochondria-targeted antioxidant MitoTEMPO improves the post-thaw sperm quality: X. Lu, et al.; Cryobiology
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SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation: A. Kumar & C. Shaha; Sci. Rep.
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Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility: H. Qi, et al.; Diabetes
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Ionizing Radiation Induces Innate Immune Responses in Macrophages by Generation of Mitochondrial Reactive Oxygen Species: S. Kim, et al.; Radiat Res.
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Induction of Lipotoxic Brain Microvascular Injury is Mediated by Activating Transcription Factor 3-Dependent Inflammatory and Oxidative Stress Pathways: H.H. Aung, et al.; J. Lipid Res.
57, 955 (2016),
Application(s): Cell culture,
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Full Text
MAVS maintains mitochondrial homeostasis via autophagy: X. Sun, et al.; Cell Discov.
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Application(s): Cell culture,
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Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A: C. Xu, et al.; Neuropharmacology
105, 270 (2016),
Application(s): Cell culture,
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Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia: C. McCarthy & L.C. Kenny; Sci. Rep.
6, 32683 (2016),
Application(s): Mitochondrial-targeted antioxidant capacity assays in HUVEC ,
Abstract;
Full Text
HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation: S.J. Han, et al.; Cell. Death Dis.
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Krüppel-like factor 6 regulates mitochondrial function in the kidney: S.K. Mallipattu, et al.; J. Clin. Invest.
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Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation: W.K. Ip, et al.; Nat. Commun.
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Metabolic regulation of the ultradian oscillator Hes1 by Reactive Oxygen Species: S. Ventre, et al.; J. Mol. Biol.
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Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy: R. Ni, et al.; Free Radic. Biol. Med.
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Application(s): Cell culture in diabetic mice,
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Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury: N.K. Patil, et al.; Am. J. Physiol. Renal. Physiol.
306, 34 (2014),
Application(s): Injection,
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Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes: Q. He, et al.; Oxid. Med. Cell. Longev.
2014, 654198 (2014),
Application(s): Detection of cellular and mitochondrial ROS levels, Mito-Tempo effect on tafazzin knockdown,
Abstract;
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Angiotensin II-induced production of mitochondrial ROS: Potential mechanisms and relevance for cardiovascular disease: S.I. Dikalov & R.R. Nazarewicz; Antioxid. Redox Signal.
19, 1085 (2013),
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The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis: Z. Wang, et al.; PLoS One
8, e75044 (2013),
Application(s): Flow Cytometry, Western Blotting, Detection of cellular and mitochondrial ROS levels,
Abstract;
Full Text
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway: J.D. Schilling, et al.; J. Immunol.
190, 1285 (2013),
Application(s): Mitochondria-targeted antioxidant in macrophages,
Abstract;
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Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation: C. Juliana, et al.; J. Biol. Chem.
287, 36617 (2012),
Application(s): Immunoblotting,
Abstract;
Full Text
Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel: M. Liu, et al.; Circ. Res.
107, 967 (2010),
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SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery: H.L. Liang, et al.; Free Rad. Biol. Med.
49, 1550 (2010),
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Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res.
107, 106 (2010),
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Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells: H.L. Liang, et al.; Apoptosis
14, 1176 (2009),
Abstract;
General Literature References
Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol.
47, 629 (2007), Review,
Abstract;
