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Mito-TEMPO

Mitochondria-targeted antioxidant
 
ALX-430-150-M005 5 mg 77.00 USD
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Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.

Product Specification

Alternative Name:(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride . monohydrate
 
Formula:C29H35N2O2ClP . H2O
 
MW:510.1 . 18.0
 
Purity:≥95% (TLC)
 
Identity:Determined by MS.
 
Appearance:Colorless film to pale orange solid.
 
Solubility:Soluble in water, DMSO, 100% ethanol or methanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Solutions in water, saline, ethanol or DMSO are stable at +4°C for 1-2 weeks. DMSO stock solution can be stored also at -20°C.
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
430-150
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430-150

Product Literature References

CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction: E. Aplak, et al.; PLoS One 15, e0227926 (2020), Abstract; Full Text
MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation: J. Zheng, et al.; Cell Death Dis. 11, 256 (2020), Abstract; Full Text
Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics: J. Nomura, et al.; Sci. Rep. 9, 17314 (2019), Abstract; Full Text
Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells: F. De Santis, et al.; PLoS One 14, e0213150 (2019), Abstract; Full Text
ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation: E. Park, et al.; Cell Death Dis. 10, 822 (2019), Abstract; Full Text
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease: G. Renga, et al.; Life Sci. Alliance 2, e201900432 (2019), Abstract; Full Text
Mitochondria-targeted antioxidant MitoTEMPO improves the post-thaw sperm quality: X. Lu, et al.; Cryobiology 80, 26 (2018), Abstract;
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation: A. Kumar & C. Shaha; Sci. Rep. 8, 615 (2018), Abstract; Full Text
Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility: H. Qi, et al.; Diabetes 66, 763 (2017), Abstract; Full Text
Ionizing Radiation Induces Innate Immune Responses in Macrophages by Generation of Mitochondrial Reactive Oxygen Species: S. Kim, et al.; Radiat Res. 187, 32 (2017), Abstract;
Induction of Lipotoxic Brain Microvascular Injury is Mediated by Activating Transcription Factor 3-Dependent Inflammatory and Oxidative Stress Pathways: H.H. Aung, et al.; J. Lipid Res. 57, 955 (2016), Application(s): Cell culture, Abstract; Full Text
MAVS maintains mitochondrial homeostasis via autophagy: X. Sun, et al.; Cell Discov. 2, 16024 (2016), Application(s): Cell culture, Abstract; Full Text
Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A: C. Xu, et al.; Neuropharmacology 105, 270 (2016), Application(s): Cell culture, Abstract;
Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia: C. McCarthy & L.C. Kenny; Sci. Rep. 6, 32683 (2016), Application(s): Mitochondrial-targeted antioxidant capacity assays in HUVEC , Abstract; Full Text
HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation: S.J. Han, et al.; Cell. Death Dis. 6, e1863 (2015), Application(s): In vivo, Abstract; Full Text
Krüppel-like factor 6 regulates mitochondrial function in the kidney: S.K. Mallipattu, et al.; J. Clin. Invest. 125, 1347 (2015), Abstract; Full Text
Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation: W.K. Ip, et al.; Nat. Commun. 6, 6931 (2015), Application(s): Cell Culture, Abstract;
Metabolic regulation of the ultradian oscillator Hes1 by Reactive Oxygen Species: S. Ventre, et al.; J. Mol. Biol. 2015, 1887 (2015), Application(s): Cell Culture, Abstract;
Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy: R. Ni, et al.; Free Radic. Biol. Med. 90, 12 (2015), Application(s): Cell culture in diabetic mice, Abstract;
Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury: N.K. Patil, et al.; Am. J. Physiol. Renal. Physiol. 306, 34 (2014), Application(s): Injection, Abstract; Full Text
Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes: Q. He, et al.; Oxid. Med. Cell. Longev. 2014, 654198 (2014), Application(s): Detection of cellular and mitochondrial ROS levels, Mito-Tempo effect on tafazzin knockdown, Abstract; Full Text
Angiotensin II-induced production of mitochondrial ROS: Potential mechanisms and relevance for cardiovascular disease: S.I. Dikalov & R.R. Nazarewicz; Antioxid. Redox Signal. 19, 1085 (2013), Abstract; Full Text
The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis: Z. Wang, et al.; PLoS One 8, e75044 (2013), Application(s): Flow Cytometry, Western Blotting, Detection of cellular and mitochondrial ROS levels, Abstract; Full Text
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway: J.D. Schilling, et al.; J. Immunol. 190, 1285 (2013), Application(s): Mitochondria-targeted antioxidant in macrophages, Abstract; Full Text
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation: C. Juliana, et al.; J. Biol. Chem. 287, 36617 (2012), Application(s): Immunoblotting, Abstract; Full Text
Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel: M. Liu, et al.; Circ. Res. 107, 967 (2010), Abstract; Full Text
SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery: H.L. Liang, et al.; Free Rad. Biol. Med. 49, 1550 (2010), Abstract;
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract;
Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells: H.L. Liang, et al.; Apoptosis 14, 1176 (2009), Abstract;

General Literature References

Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol. 47, 629 (2007), Review, Abstract;

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