Inhibits virulence regulation in V. cholerae. Prevents expression of cholera toxin and the toxin coregulated pilus (TCP) by inhibiting the transcriptional regulator ToxT. Effectively protects infant mice against TCP-dependent V. cholerae intestinal colonization in vivo. Displays little toxicity towards mammalian cells (up to 2mM for Hep2 cells).
Product Specification
| Alternative Name: | 4-(N-(1,8-Naphthalimide))-n-butyric acid, 1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-butanoic acid |
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| Formula: | C16H13NO4 |
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| MW: | 283.3 |
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| CAS: | 88909-96-0 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Off-white to yellow solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 6 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Virstatin inhibits dimerization of the transcriptional activator ToxT: E. A. Shakhnovich, et al.; PNAS
104, 2372 (2007),
Abstract;
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization: D.T. Hung, et al.; Science
310, 670 (2005),
Abstract;
