A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.
Product Details
| Alternative Name: | Camptosar, 7-ethyl-10-hydroxycamptothecin, CPT-11 |
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| Formula: | C33H38N4O6 . HCl . 3H2O |
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| MW: | 586.7 . 36.5 . 54.0 |
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| CAS: | 136572-09-3 |
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| MI: | 14: 5091 |
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| RTECS: | DW1061000 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White solid. |
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| Solubility: | Slightly soluble in methanol or water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis: Y. Takeba, et al.; J. Pharmacol. Sci.
104, 232 (2007),
Abstract;
Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer: U. Kellner, et al.; Onkologie
23, 424 (2000),
Abstract;
Therapeutic advances in small cell lung cancer: F.P. Worden and G.P. Kalemkerian; Expert Opin. Investig. Drugs
9, 565 (2000),
Abstract;
The role of irinotecan in colorectal cancer: L.B. Saltz; Curr. Oncol. Rep.
1, 155 (1999),
Abstract;
Induction of tumor necrosis factor by a camptothecin derivative, irinotecan, in mice and human mononuclear cells: S. Goto, et al.; Anticancer Res.
16, 2507 (1996),
Abstract;
