Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.
Product Details
| Alternative Name: | 2-(1H-Indol-3-yl)-3-pentylamino-maleimide |
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| Formula: | C19H23N3O2 |
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| MW: | 325.4 |
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| CAS: | 861891-50-1 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO (100mg/ml), dichloromethane, 100% ethanol or methanol (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization: H. Shi, et al.; Nat. Commun.
12, 1379 (2021),
Abstract;
Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives: K. Dodo, et al.; Bioorg. Med. Chem. Lett.
15, 3114 (2005),
Abstract;
