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IM-54

Necrosis inhibitor
 
ALX-430-137-M001 1 mg 44.00 USD
 
ALX-430-137-M005 5 mg 184.00 USD
 
ALX-430-137-M025 25 mg 521.00 USD
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Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.

Product Details

Alternative Name:2-(1H-Indol-3-yl)-3-pentylamino-maleimide
 
Formula:C19H23N3O2
 
MW:325.4
 
CAS:861891-50-1
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (100mg/ml), dichloromethane, 100% ethanol or methanol (10mg/ml).
 
Shipping:Ambient Temperature
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
430-137
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Product Literature References

N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization: H. Shi, et al.; Nat. Commun. 12, 1379 (2021), Abstract;
Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives: K. Dodo, et al.; Bioorg. Med. Chem. Lett. 15, 3114 (2005), Abstract;

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