Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Product Details
| Alternative Name: | KN-93 (water soluble), 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate |
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| Formula: | C26H29ClN2O4S . H3PO4 |
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| MW: | 501.0 . 98.0 |
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| CAS: | 1188890-41-6 |
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| Purity: | ≥98% (1H-NMR) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or water. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ.
6, 1063 (1995),
Abstract;
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC
195, 608 (1993),
Abstract;
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC
191, 255 (1993),
Abstract;
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC
181, 968 (1991),
Abstract;
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