Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Cobalt (III) Protoporphyrin IX chloride

Heme oxygenase activator
ALX-430-076-M025 25 mg 130.00 USD
Do you need bulk/larger quantities?
The ability of cobalt ions to induce heme oxygenase (HO) activity in liver cells was first reported almost 30 years ago. Cobalt protoporphyrin IX (CoPP) was later shown to be a substrate for HO, now identified as the inducible isoform HO-1 (heast shock protein 32; hsp32). CoPP has been shown to down-regulate various cytochrome P450 isoforms and various mechanisms of action have been attributed to CoPP and other metalloporphyrins.

Product Details

Formula:C34H32CoN4O4 . Cl
Purity:≥95% (TLC)
Identity:Identity determined by UV/VIS and NMR.
Appearance:Dark purple solid.
Solubility:Soluble in basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes: A. Nithichanon, et al.; Sci. Rep. 10, 10297 (2020), Abstract; Full Text
Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR: N.G. Abraham et al.; Cell Mol Biol (Noisy-le-grand) 48, 895 (2002), Abstract;
Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury: F. Amersi et al.; J. Clin. Invest. 104, 1631 (1999), Abstract;
Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response: E.E. Cable et al.; Mol. Cell. Biochem. 169, 13 (1997), Abstract;
Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein: D.W. Rosenberg et al.; Pharmacology 51, 254 (1995), Abstract;
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver: M.D. Maines et al.; PNAS 73, 1499 (1976), Abstract;
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase: B.A. Schacter & M.R. Waterman; Life Sci. 14, 47 (1974), Abstract;
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity: M.D. Maines & A. Kappas ; PNAS 71, 4293 (1974), Abstract;

Product Toolbox


Certificate of Analysis


By target:
Heme oxygenase
By biological activity:
Heme oxygenase Activator
By catalog section:


Technical Service
Customer Service

Related Literature

Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

All new literature pieces