The ability of cobalt ions to induce heme oxygenase (HO) activity in liver cells was first reported almost 30 years ago. Cobalt protoporphyrin IX (CoPP) was later shown to be a substrate for HO, now identified as the inducible isoform HO-1 (heast shock protein 32; hsp32). CoPP has been shown to down-regulate various cytochrome P450 isoforms and various mechanisms of action have been attributed to CoPP and other metalloporphyrins.
Product Details
| Formula: | C34H32CoN4O4 . Cl |
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| MW: | 654.5 |
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| CAS: | 102601-60-5 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Identity determined by UV/VIS and NMR. |
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| Appearance: | Dark purple solid. |
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| Solubility: | Soluble in basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes: A. Nithichanon, et al.; Sci. Rep.
10, 10297 (2020),
Abstract;
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Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR: N.G. Abraham et al.; Cell Mol Biol (Noisy-le-grand)
48, 895 (2002),
Abstract;
Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury: F. Amersi et al.; J. Clin. Invest.
104, 1631 (1999),
Abstract;
Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response: E.E. Cable et al.; Mol. Cell. Biochem.
169, 13 (1997),
Abstract;
Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein: D.W. Rosenberg et al.; Pharmacology
51, 254 (1995),
Abstract;
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver: M.D. Maines et al.; PNAS
73, 1499 (1976),
Abstract;
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase: B.A. Schacter & M.R. Waterman; Life Sci.
14, 47 (1974),
Abstract;
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity: M.D. Maines & A. Kappas ; PNAS
71, 4293 (1974),
Abstract;
