Liver-selective nitric oxide (NO) donor. Blocks TNF-α-induced apoptosis and toxicity.
Product Details
| Alternative Name: | O2-Vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate |
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| Formula: | C6H11N3O2 |
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| MW: | 157.2 |
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| CAS: | 179344-98-0 |
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| Formulation: | Solution in ethanol (5mg V-PYRRO/NO in approx. 5µl USP ethanol). |
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| Purity: | ≥98% (HPLC (UV)) |
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| Identity: | Determined by 1H-NMR and UV/VIS. |
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| Appearance: | Pale yellow oil. |
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| Solubility: | Soluble in DMSO or dimethyl formamide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Always use fresh solutions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats: F. Moal, et al.; World J. Gastroenterol.
12, 6639 (2006),
Abstract;
Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450: K. Inami, et al.; Nitric Oxide
14, 309 (2006),
Abstract;
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice: J. Liu, et al.; Biochem. Pharmacol.
70, 144 (2005),
Abstract;
Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO: J. Liu & M.P. Waalkes; Toxicology
208, 289 (2005), (Review),
Abstract;
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB: K. Chang, et al.; Exp. Mol. Med.
36, 311 (2004),
Abstract;
Full Text
The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice: J. Liu, et al.; J. Pharmacol. Exp. Ther.
310, 18 (2004),
Abstract;
Full Text
The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level: W. Qu, et al.; Nitric Oxide
12, 114 (2004),
Abstract;
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-a-induced apoptosis and toxicity in the liver: J.E. Saavedra, et al.; J. Med. Chem.
40, 1947 (1997),
Abstract;
