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Nitric oxide donor
ALX-430-075-M005 5 mg 35.00 USD
ALX-430-075-5005 5x5 mg 125.00 USD
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Liver-selective nitric oxide (NO) donor. Blocks TNF-α-induced apoptosis and toxicity.

Product Details

Alternative Name:O2-Vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
Formulation:Solution in ethanol (5mg V-PYRRO/NO in approx. 5µl USP ethanol).
Purity:≥98% (HPLC (UV))
Identity:Determined by 1H-NMR and UV/VIS.
Appearance:Pale yellow oil.
Solubility:Soluble in DMSO or dimethyl formamide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Handling:Always use fresh solutions.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats: F. Moal, et al.; World J. Gastroenterol. 12, 6639 (2006), Abstract;
Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450: K. Inami, et al.; Nitric Oxide 14, 309 (2006), Abstract;
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice: J. Liu, et al.; Biochem. Pharmacol. 70, 144 (2005), Abstract;
Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO: J. Liu & M.P. Waalkes; Toxicology 208, 289 (2005), (Review), Abstract;
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB: K. Chang, et al.; Exp. Mol. Med. 36, 311 (2004), Abstract; Full Text
The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice: J. Liu, et al.; J. Pharmacol. Exp. Ther. 310, 18 (2004), Abstract; Full Text
The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level: W. Qu, et al.; Nitric Oxide 12, 114 (2004), Abstract;
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-a-induced apoptosis and toxicity in the liver: J.E. Saavedra, et al.; J. Med. Chem. 40, 1947 (1997), Abstract;

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