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United States 

MnTMPyP . pentachloride

SOD mimetic. Peroxynitrite scavenger.
ALX-430-070-M010 10 mg 38.00 USD
ALX-430-070-M050 50 mg 66.00 USD
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Replaces Prod. #: BML-FR108

Cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Catalyzes the dismutation of O2- even in the presence of excess EDTA. Displays a protective effect against H2O2 mediated injury in astroglial cells.

Product Details

Purity:≥95% (TLC)
Appearance:Black crystalline powder.
Solubility:Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).
Long Term Storage:-20°C
Handling:Prepare fresh solutions daily, immediately prior to use
Regulatory Status:RUO - Research Use Only
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Product Literature References

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex: A. Cinti, et al.; MBio 7, e00329 (2016), Application(s): Cell culture, Abstract; Full Text
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure: A.A. Miller, et al.; Br. J. Pharmacol. 131, 29 (2000), Abstract;
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta: A. MacKenzie, et al.; Br. J. Pharmacol. 127, 1159 (1999), Abstract;
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells: R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand) 45, 1053 (1999), Abstract;
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998), Abstract;
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998), Abstract; Full Text
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996), Abstract;
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli: S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys. 321, 271 (1995), Abstract;
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994), Abstract; Full Text

General Literature References

Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells: B.E. Dwyer, et al.; J. Neurochem. 71, 2497 (1998), Abstract;

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