Replaces Prod. #: BML-FR108
Cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Catalyzes the dismutation of O2- even in the presence of excess EDTA. Displays a protective effect against H2O2 mediated injury in astroglial cells.
Product Details
| Formula: | C44H36MnN8Cl5 |
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| MW: | 909.0 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Black crystalline powder. |
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| Solubility: | Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Prepare fresh solutions daily, immediately prior to use |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex: A. Cinti, et al.; MBio
7, e00329 (2016),
Application(s): Cell culture,
Abstract;
Full Text
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure: A.A. Miller, et al.; Br. J. Pharmacol.
131, 29 (2000),
Abstract;
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta: A. MacKenzie, et al.; Br. J. Pharmacol.
127, 1159 (1999),
Abstract;
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells: R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand)
45, 1053 (1999),
Abstract;
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol.
53, 795 (1998),
Abstract;
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem.
273, 24521 (1998),
Abstract;
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Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys.
325, 20 (1996),
Abstract;
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli: S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys.
321, 271 (1995),
Abstract;
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem.
269, 23471 (1994),
Abstract;
Full Text
General Literature References
Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells: B.E. Dwyer, et al.; J. Neurochem.
71, 2497 (1998),
Abstract;
