Depolymerizes microtubules and inhibits their formation. Induces apoptosis.
Product Details
| Alternative Name: | Demecolcine |
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| Formula: | C21H25NO5 |
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| MW: | 371.4 |
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| Source: | Semisynthetic from colchicine (Prod. No. ALX-380-033). |
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| CAS: | 477-30-5 |
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| MI: | 14: 2887 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and TLC. |
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| Appearance: | Light yellow powder. |
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| Solubility: | Soluble in 100% ethanol, chloroform or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solutions are stable for at least 6 months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res.
100, 224 (2003),
Abstract;
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol.
46, 79 (2000),
Abstract;
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC
266, 279 (1999),
Abstract;
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry
31, 295 (1998),
Abstract;
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res.
219, 159 (1995),
Abstract;
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo)
35, 41 (1994),
Abstract;
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res.
215, 373 (1994),
Abstract;
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci.
102, 387 (1992),
Abstract;
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res.
31, 494 (1992),
Abstract;
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol.
456, 591 (1992),
Abstract;
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res.
198, 214 (1992),
Abstract;
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