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ALX-430-033-M001 1 mg 51.00 USD
ALX-430-033-M005 5 mg 111.00 USD
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Depolymerizes microtubules and inhibits their formation. Induces apoptosis.

Product Details

Alternative Name:Demecolcine
Source:Semisynthetic from colchicine (Prod. No. ALX-380-033).
MI:14: 2887
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR and TLC.
Appearance:Light yellow powder.
Solubility:Soluble in 100% ethanol, chloroform or DMSO.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stock solutions are stable for at least 6 months when stored at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation: W. Li, et al.; Nat. Commun. 13, 7414 (2022), Abstract;
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003), Abstract;
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000), Abstract;
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999), Abstract;
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998), Abstract;
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995), Abstract;
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994), Abstract;
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994), Abstract;
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992), Abstract;
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res. 31, 494 (1992), Abstract;
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol. 456, 591 (1992), Abstract;
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res. 198, 214 (1992), Abstract;

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