Replaces Prod. #: BML-EI202
Inhibitor of diacylglycerol kinase in intact cells (IC50=0.12µM) and in isolated membranes (IC50=0.3µM). More potent analog of R59 022 (Prod. No. ALX-430-027). Useful for elucidating roles of protein kinase C (PKC).
Product Details
| Alternative Name: | 3-[2-[4-[bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
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| Formula: | C28H25F2N3OS |
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| MW: | 489.6 |
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| CAS: | 120166-69-0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in dichloromethane, ethyl acetate, tetrahydro-furan, DMSO (33mg/ml) or dimethyl formamide; almost insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth: P. Depeille, et al.; Nat. Cell. Biol.
17, 804 (2015),
Application(s): Cell Culture,
Abstract;
The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy: J.S. You, et al.; J. Biol. Chem.
289, 1551 (2014),
Abstract;
Full Text
Lysophosphatidic acid acyltransferase beta regulates mTOR signaling: M.A. Blaskovich, et al.; PLoS One
8, e78632 (2013),
Application(s):MiaPaCa2 cells treatment,
Abstract;
Full Text
The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem.
264, 3274 (1989),
Abstract;
Full Text
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem.
260, 15762 (1985),
Abstract;
Full Text
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